Celebrities on GLP-1s: What They’ve Said About Their Weight Loss Journeys
GLP-1 medications have gone from something many people had never heard of to one of the biggest conversations in weight loss—and celebrities have played a major role in bringing them into the spotlight.
Over the past few years, stars have become increasingly open about their experiences with medications like Wegovy, Zepbound, and Mounjaro. And their stories haven't all been the same.
Some turned to GLP-1s after years of struggling to lose weight through diet and exercise. Others have talked about finally quieting constant thoughts about food, overcoming weight-loss plateaus, or finding an approach that worked when previous attempts hadn't.
So rather than focusing only on celebrity before-and-after photos, we're looking at what they've actually said about their GLP-1 weight-loss journeys—and what their experiences can teach anyone considering one of their own.
Celebrities on GLP-1s
Oprah Winfrey: Rethinking Weight, Willpower, and Shame
Few celebrities have had their weight discussed as publicly – or for as long – as Oprah Winfrey.
For decades, Winfrey openly discussed dieting, weight fluctuations, and the criticism she experienced because of her body. But her perspective on weight management changed as she learned more about obesity and prescription weight-loss medications.
Winfrey revealed in 2023 that she had begun using a doctor-prescribed weight-loss medication, although she did not initially identify the specific drug. She explained that learning more about the biology of obesity helped her reconsider the belief that managing weight was simply a matter of willpower. She has since become one of the most prominent voices discussing GLP-1 medications and the stigma surrounding medical treatment for obesity.
What can we take from Oprah Winfrey's experience?
Needing additional support for weight management doesn't mean someone hasn't tried hard enough. Weight is influenced by much more than motivation alone, and for some people, medically supervised treatment may become one part of a broader weight-management plan.
Serena Williams: When Diet and Exercise Didn't Feel Like Enough
Serena Williams' story challenges one of the biggest assumptions surrounding GLP-1 weight loss: "Why not just exercise more?"
We're talking about one of the greatest athletes of all time.
Williams revealed in 2025 that she was taking Zepbound after struggling with postpartum weight loss following the births of her children. She told ELLE that after her second child, she was walking as many as 30,000 steps a day, running, training, and paying attention to her nutrition – but still wasn't seeing the changes she wanted.
Williams said she ultimately decided she needed to try something different. She has since reported losing 31 pounds while using Zepbound and has spoken openly about wanting to reduce the stigma surrounding GLP-1 medications.
What can we take from Serena Williams' experience?
Healthy eating and exercise remain important, but weight management isn't always as straightforward as "eat less and move more." Someone can be extremely active and still struggle to reach their weight goals.
For people experiencing something similar, the next step may be exploring a structured, medically guided approach like our Weight Loss Program, where you can speak with a healthcare provider about why weight loss has been difficult and whether additional treatment options are appropriate.
Amy Schumer: When One GLP-1 Wasn't the Right Fit
Amy Schumer's experience highlights another side of the celebrity GLP-1 conversation: Not every medication works the same way for every person.
Schumer has said she previously tried Wegovy and lost weight quickly, but experienced significant side effects and ultimately stopped taking it. She later revealed that she was using Mounjaro and described having a much better experience with that treatment.
Her story is an important reminder that seeing someone else's success with a particular GLP-1 doesn't mean you'll have the same experience.
What can we take from Amy Schumers' experience?
Treatment should be personalized.
Side effects matter. Your medical history matters. How you feel matters.
And if one approach isn't working well for you, that doesn't mean you should simply increase your dose, ignore your symptoms, or copy someone else's treatment plan.
Our Weight Loss Program can help you determine what’s appropriate for you based on your individual health history, goals, and eligibility.
Whoopi Goldberg: Discovering a Medical Option That Helped
Whoopi Goldberg has also been open about using Mounjaro. Goldberg explained that her weight had increased while she was taking steroids and other medications and that she hadn't initially realized how much her body had changed.
She later shared that Mounjaro was one of the tools that helped her lose weight. Her experience highlights something that can easily get lost when we talk about celebrity transformations: weight gain and weight loss happen within the context of someone's overall health.
Medications, medical conditions, age, lifestyle, hormones, and countless other factors can affect someone's body. That's why looking at a dramatic before-and-after photo tells you very little about what actually happened in between.
The Biggest Lesson? There Isn't One GLP-1 Experience
Look at these stories side by side and something becomes clear - One person may experience significant weight loss and another may struggle with side effects. Someone else may find that a particular medication doesn't work well for them while another may discover that medical treatment finally helps after years of trying other approaches.
That's why asking "What GLP-1 are celebrities taking?" may be interesting – but it isn't necessarily the most useful question when you're thinking about your own health.
The better question is: "What weight-loss approach is right for me?"
Celebrity Results Aren't Your Results
It's completely understandable to see a celebrity transformation and wonder: Could that happen to me?
But celebrity before-and-after photos can only tell you so much.
You usually don't know someone's:
Starting weight
BMI or body composition
Medical history
Exact treatment plan
Medication dose
Nutrition
Exercise routine
Side effects
Other medications
Length of treatment
Ongoing medical support
Even if two people take exactly the same GLP-1 medication, their results may look very different. That's why your weight-loss journey shouldn't be built around recreating someone else's transformation. It should be built around you.
You Don't Need Someone Else's Before-and-After. Visualize Your Own.
One of the most tempting parts of celebrity GLP-1 stories is seeing the transformation.
But instead of scrolling through other people's before-and-after photos and wondering "What would I look like?", our Weight Loss Program gives you a more personalized way to explore your own journey.
Our AI Weight Loss Simulator allows you to visualize potential changes to your own body based on your starting point and goals. Instead, it's designed to help you visualize possibilities, set goals, and see your progress in a way that goes beyond the number on the scale.
Throughout your journey, you can also track changes over time – giving you a clearer picture of how far you've come.
Your GLP-1 Journey Should Start With You
Celebrity stories can help normalize conversations around weight-loss medication. But they shouldn't determine your treatment.
Our Weight Loss Program starts by learning about you – your health history, your weight-loss goals, and your individual needs.
If you're eligible, you'll meet virtually with a licensed healthcare provider who can discuss whether GLP-1 treatment may be medically appropriate and which treatment options may make sense for you.
If prescribed, your program can include:
Because the goal isn't to get Oprah's results. Or Serena's. Or anyone else's. It's to discover what progress can look like for you.
Considering a GLP-1? Start With the Right Question
Celebrity GLP-1 transformations may have helped bring medications like Wegovy, Zepbound, and Mounjaro into everyday conversation. And there's value in celebrities being open about their experiences – both the positive ones and the difficult ones.
But their stories also reinforce an important truth:
GLP-1 treatment isn't one-size-fits-all.
Before worrying about which medication a celebrity took or how many pounds someone else lost, find out what's medically appropriate for your body.
With our Weight Loss Program, you can start with a simple assessment, meet with a licensed provider if eligible, and explore a personalized approach to your weight-loss journey.
Because your best before-and-after shouldn't look like someone else's. It should look like you.
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